2nd Month Vaccines: List, Safety, Purpose And Side Effects

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Timely vaccination is essential to ensure babies develop sufficient immunity against potentially deadly diseases. Hence, it is important to know when specific vaccines should be administered; for example, some essential 2-month vaccines include polio and rotavirus vaccinations.

Vaccines are developed after extensive research on their safety and efficacy for widespread use (1). Though vaccines are of different types, most comprise an inactive or weak form of the pathogen or its toxin. They are called antigens and stimulate the immune system to produce antibodies, providing immunity (2).

Read this article to learn about the vaccines an infant should get in their second month, the possible side effects of the vaccines, and how to manage them.

Vaccines Scheduled For A Two-month-old Baby

According to the Centers for Disease Control and Prevention (CDC), the following vaccines are given to babies at one to two months of age (3).

1. Hepatitis B (HepB) vaccine

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• Hepatitis B is a contagious viral liver disease, which may cause extensive liver damage.

• The first dose of the HepB vaccine is given immediately after birth, the booster dose is given one or two months after birth, and the final dose is given anytime between six to 18 months.

• According to the CDC, the HepB vaccine is safe and effective against HepB infection.

• It may cause mild side effects such as a sore arm from the shot and low-grade fever (less than 101°F or 38.3°C) (4).

2. Diphtheria, tetanus, and pertussis (DTaP) vaccine

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• Children are given five doses of DTaP.

• The first dose is given at the age of two months, followed by one booster dose each at four months, six months, 15 to 18 months, and four to six years of age.

• Mild side effects of DTaP are redness, pain, or swelling of the injection site, fever, and vomiting.

• Severe but rare complications of DTaP vaccines are high-grade fever (over 105°F or 40°C), inconsolable crying for three hours or more, and seizures (5).

The following are the symptoms and modes of transmission of diphtheria, tetanus, and pertussis.

• Diphtheria: Diptheria is a bacterial disease that can start with a sore throat, mild fever, and chills. It may also cause a coating in the back of the nose or the throat, making it difficult to breathe or swallow. The disease spreads through sneezing and coughing (6). It is important to note that the overall case-fatality rate for diphtheria is 5%–10%, with higher death rates (up to 20%) among persons younger than five and older than 40, as per a CDC report.

• Tetanus: Tetanus is caused by toxins produced by the tetanus bacteria found in soil, dust, and manure. The bacteria may enter the body through punctures, cuts, sores, burns, or animal bites. The toxins affect the muscles, causing stiffness and spasms. Severe cases may affect respiratory muscles, increasing the risk of respiratory muscles paralysis and death (7).

• Pertussis or whooping cough: Whooping cough is a respiratory infection caused by Bordetella pertussis that spreads through coughing and sneezing. The most notable sign of the illness is violent coughing with a whooping sound. Untreated cases may lead to severe pneumonia and respiratory failure in infants (8).

Quick fact

One more dose of the DTaP vaccine is administered at around eleven to twelve years (6).

3. Pneumococcal vaccine (PCV13)

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• Pneumococcal disease is caused by the pneumococcus bacteria that spread through coughing and sneezing.

• Pneumococcal disease affects the ears, lungs, blood, and brain.

• Common symptoms include high fever, cough, chest pain, and body pain.

• The disease may lead to severe complications, such as meningitis, if left untreated.

• The first dose of the vaccine is given at two months of age, followed by booster doses at the age of four months, six months, and between 12 and 15 months.

• Side effects of the PCV13 vaccine are usually very mild. These may include fussiness, lethargy, loss of appetite, local reactions at the injection site (redness, swelling, or pain), fever, chills, or headache (9).

4. Haemophilus influenzae type b (Hib) vaccine

• Hib disease is a severe illness caused by the bacteria Haemophilus influenzae type b (Hib) bacteria.

• The bacteria usually affects the nervous system, causing encephalitis and/or meningitis. The symptoms include high fever, headache, poor appetite, and vomiting.

• The first dose of the vaccine is given at two months, followed by booster doses at four months, six months, and between 12 and 15 months.

• Hib vaccine has very mild side effects such as fever and local reactions at the injection site, such as redness, swelling, or pain (10).

5. Polio (IPV) vaccine

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• Polio or poliomyelitis is a disabling disease caused by the poliovirus.

• The virus can infect the spinal cord and nerves, causing irreversible paralysis and respiratory failure.

• It is a highly contagious disease that spreads through food and water contaminated with respiratory droplets or feces.

• The child gets one dose each at two months, four months, between six and 18 months, and between four and six years.

• Redness, swelling, and pain might occur at the injection site if the baby received the injectable variant of the vaccine (11). The oral polio vaccine, which is less commonly given, causes no side effects.

Point to consider

Children traveling to countries with a higher risk of contracting polio should complete all the recommended shots before travel. Their doctor may recommend an accelerated polio schedule if they cannot complete the routine series before leaving (11).

6. Rotavirus (RV) vaccine

• Rotavirus infection causes severe diarrhea and vomiting accompanied by fever, stomach pain, and loss of appetite. The infection primarily affects infants.

• Severe dehydration is the leading complication of the disease and a common cause of fatality.

• There are two types of rotavirus vaccines, RotaTeq (RV5) and Rotarix (RV1).

• RV5 is given in three dosages at ages two months, four months, and six months. RV1 is given in two dosages at ages two months and four months.

• Rotavirus vaccines are given in the form of oral drops and not injections.

• Mild side effects include fussiness, diarrhea, and vomiting.

• A rare complication is intussusception, a condition where a section of the intestine folds on the adjacent part. It is estimated to occur in one out of 20,000 to 100,000 vaccinated babies (12).

Preparing A Two-month-old For Vaccine Shots

The following steps could help you comfort your baby before, during, and after vaccination (13).

• Pack the baby’s favorite toy, pacifier, or blanket to make them feel cozy and comfortable.

• Check with the pediatrician if they can give a safe sweet-tasting solution to your baby right before the vaccination. This can help distract the baby from pain and reduce crying.

• If possible, breastfeed your baby during the vaccine administration to soothe and calm them down.

• You may check with the pediatrician if they can apply a pain-relieving ointment or spray before vaccine administration.

• You may distract the baby by singing their favorite songs or rhymes.

• You may also give them a pacifier to calm them down.

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• You may swing and rock them in your arms immediately after vaccination. Another alternative is to distract them with something interesting.

• Cuddle them often after the vaccination. You may also breastfeed them immediately after vaccination to calm down the fussiness caused by the pain at the injection site.

Helping The Baby With Side Effects

Local reactions at the injection site, such as pain, redness, or swelling, are common and resolve within a day or two after vaccination in babies. Some babies may develop rashes and fever that usually last no more than a few days and do not pose any severe health risks.

The following tips will help you manage mild vaccine side effects at home (13).

• Ask the pediatrician about the side effects and abnormal effects.

• Use a cool, damp cloth to reduce local irritation, redness, swelling, or soreness.

• Use cool pads to reduce the fever.

• Ensure the baby gets adequate rest.

• Ask the healthcare provider if they can prescribe a baby-safe pain reliever, including pain-relieving topical ointments.

• Check with your doctor if you suspect or notice anything unusual.

Infographic: What Are The Scheduled Vaccines For A Two-Month-Old Baby

Vaccinations play an important role in protecting infants from preventable diseases. This infographic below explores the recommended immunization regimen for two-month-old babies. Numerous vaccination schedules begin as early as two months of age, and being aware of these schedules will help you stay updated and protect your babies from potentially fatal illnesses.

Illustration: Momjunction Design Team

Key Pointers

Help your baby feel better after their 2-month shots with these simple tips. Learn how to soothe their discomfort and provide comfort.

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Reviewer Author Editor Fact Checker

Dr. Jessica MaddenMD, FAAP, IBCLC

Jessica Madden is a pediatrician, neonatologist, lactation consultant, and mother of four, who has been taking care of newborns for more than 19 years now. She works as a neonatologist in the NICU at Rainbow Babies and Children’s Hospital in Cleveland, Ohio, and founded Primrose Newborn Care, a newborn medicine and “4th trimester” home-visiting and telemedicine practice, in 2018.

Read full bio of Dr. Jessica Madden

Dr. Ritika ShahBDS, CLC

Dr. Ritika Shah is a certified lactation counsellor (CLC) from iNational Health Care Academy, Singapore and a dental surgeon with more than seven years of clinical experience across various cities in India. She did her graduation in Dentistry from KM Shah Dental College.

Read full bio of Dr. Ritika Shah

Rohit GarooBSc, MBA

Rohit Garoo is a writer-turned-editor with over 9 years of experience in content writing, editing, and content marketing. He did his bachelors in Science at St. Xavier's College, Hyderabad, and masters in Business Administration at Osmania University.

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Ghazia ShahMSc, MA, BEd

Ghazia is a scientist-turned-writer with three years of research experience in Cancer Biology. She did her masters degree in Biotechnology at the University of Kashmir and bachelors in Education at the same university. Ghazia then delved deeper into the science of language with a masters in English.

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