Corpus Luteum Cyst In Pregnancy: Symptoms And Treatment

These support pregnancy and resolve on their own but if they persist, seek medical advice.

Medically reviewed by Dr. Richa Hatila Singh, MS Dr. Richa Hatila Singh Dr. Richa Hatila SinghMS MomJunction on Facebook Specialty: Obstetrics & GynecologyExperience: 14 years
Written by , MSc Aneesha Amonz MSc Follow MomJunction on Linkedin Specialty: Health and WellnessExperience: 2 years
Edited by , BSc Rebecca Malachi BSc Follow MomJunction on Linkedin Specialty: Pregnancy, Health and WellnessExperience: 12 years
Fact-checked by , MSc Reshmi Das MSc Follow MomJunction on Linkedin Specialty: Health and WellnessExperience: 4 years
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Corpus Luteum Cyst During Pregnancy

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Corpus luteum cystsiFluid-filled, benign growths that form on or under the skin during pregnancy are common ovarian cysts formed when the corpus luteum (cluster of cells in which the egg seals itself) fails to shrink after about 12 weeks of pregnancy, causing it to fill with fluid. The corpus luteum produces progesteroneiA female reproductive hormone that plays an important role in menstruation, pregnancy, and breastfeeding that helps prepare the endometrial lining for implantation. These cysts are common during pregnancy and not usually troublesome. But, if these are not treated immediately, they might continue to grow, rupture and twist, giving rise to pregnancy complications (1) (2) (3).

Read on to know about the symptoms, causes, and treatments for corpus luteum cyst in pregnancy.

In This Article

Are Corpus Luteum Cysts Normal In Pregnancy?

If the corpus luteum cyst persists, doctors suggest ultrasounds.

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Corpus luteal cysts are among the most common functional ovarian cysts during pregnancy. When the corpus luteum cyst develops into a luteal cyst, it continues to produce progesterone to support the pregnancy and is mostly harmless. The cyst gradually disappears at the start of the second trimester.

If the corpus luteum cyst persists for a long time, your doctor may recommend regular ultrasounds to monitor the cyst and observe if any signs of cyst rupture or torsion exist (1) (4).

protip_icon Quick fact
The size of corpus luteum cysts rarely exceeds five centimeters (20).

Corpus Luteum And The Menstrual Cycle

The corpus luteum releases progesterone and plays an integral part in the menstrual cycle, which proceeds in three distinct phases (5) (6):

  • Follicular phase: The follicular phase begins on the first day of the menstrual period and continues for around 14 days. During this phase, the pituitary gland secretes a high level of follicle-stimulating hormoneiA hormone responsible for male and female sexual development and reproduction (FSH) and luteinizing hormoneiA hormone responsible for male and female sexual development and functioning (LH) into the blood supply, inducing the maturation of the follicles containing eggs.

One of the follicles, known as the dominant follicle, grows faster than the others and causes an increase in estrogeniA sex hormone responsible for the development of female sexual characteristics levels by day seven. The estrogen then suppresses the level of FSH and increases that of LH, thereby marking the beginning of the ovulatory phase.

  • Ovulatory phase: The ovulation phase occurs on day 13 or 14 of the menstrual period. As the level of LH in the blood increases, the egg in the dominant follicle completely matures and releases. The follicle then contracts into a cluster of cells called the corpus luteum, marking the beginning of the luteal phase.
  • Luteal phase: This phase usually begins on day 15 with the corpus luteum producing an increased level of progesterone. It induces the development of the uterus’s endometrium lining to implant the sperm-fertilized egg and helps sustain the pregnancy.

The corpus luteum produces progesterone up to ten weeks of pregnancy, after which it shrinks and eventually disappears.

If pregnancy does not occur, the progesterone and estrogen levels gradually decrease, causing the endometrium lining to fall off, which induces menstrual bleeding.

Symptoms Of Corpus Luteum Cysts

Unexplained weight gain is a symptom of corpus luteam cysts.

Image: Shutterstock

Functional ovarian cysts, such as corpus luteal cysts, generally do not present symptoms and can disappear without treatment. However, when ovarian cyst symptoms manifest, they could include (3) (7)

  • Constant pelvic pain or pain before and at the beginning of a period
  • Pain during intercourse
  • Unusual bloating or swelling of the abdomen
  • Unexplained weight gain
  • Abnormal vaginal bleeding and heightened menstrual cramps
  • Difficulty or pain during urination and bowel movements
  • Frequent urination

protip_icon Be watchful
Ovarian cysts may also cause nausea, vomiting, lightheadedness, and weakness (21).

Identifying Corpus Luteum Cysts

A corpus luteum cyst is detected through a transvaginal ultrasound.

Image: Shutterstock

A corpus luteum cyst is usually detected through a transvaginal ultrasound using a transducer. When placed in the vagina, the transducer produces sound waves that help visualize the ovary and the cysts, if any. In addition, a transvaginal ultrasound enables the doctors to identify the cyst’s location, size, and shape and determine if it is fluid-filled or solid (8).

This cyst can also be detected through a transabdominal ultrasound, where the transducer is placed on the abdomen to visualize the cyst (9).

Risk Factors Of Corpus Luteum Cyst

Endometriosis can be a risk factor for corpus luteam cyst.

Image: Shutterstock

While corpus luteum cysts are a common occurrence and can appear irrespective of additional influences, certain risk factors can increase the possibility of their appearance in some women (9) (10)

  • Fertility medications: The most commonly prescribed fertility drug is clomiphene, given to women facing difficulty in conceiving or women with PCOSiA hormonal condition in females characterized by irregular periods, cysts on the ovaries, weight gain, and excess body hair . PCOS interferes with the production of the pregnancy hormones that release the eggs from the follicles. These medications could create a hormonal imbalance resulting in an ovarian cyst.
  • Endometriosis: As stated by the World Health Organization, Endometriosis affects roughly 10% (190 million) of reproductive-age women and girls worldwide. This condition causes the tissue lining the uterus to grow on its outside. Women with endometriosis are at a higher risk of developing a corpus luteal cyst.
  • Pregnancy: Pregnant women may be at greater risk of the cyst; however, a corpus luteum cyst can also develop in nonpregnant women.
  • Ectopic pregnancy: The condition where the egg implants outside of the uterus, either in the fallopian tubesiMuscular, hollow ducts connecting the uterus with the ovaries to transport eggs during ovulation or the ovary. The probability of developing a corpus luteum cyst may be higher in women with ectopic pregnancy.

When To Seek Emergency Care

Corpus luteum cysts generally do not require any medical attention and disappear over time. However, if you experience acute abdominal pain, abnormal bleeding, and high temperature, check with your healthcare provider as these could be symptoms of an ovarian cyst rupture or a torsion (7).

Treatment For Corpus Luteum Cyst

Seek medical treatment in case of extreme symptoms and complications. The treatment may be as follows (3) (7).

  • Observation: For mild symptoms that do not cause any discomfort, your healthcare practitioner may recommend regular observation through routine ultrasounds and physical examination until the symptoms subside.
  • Oral contraceptives: Birth control pills may be prescribed, which can help prevent the risk of recurrence of the ovarian cyst. Your healthcare practitioner may also prescribe pain relief medication.
  • Laparoscopy: In severe pain or ovarian cyst rupture or torsion, laparoscopic surgery may be recommended. In this surgery, a tube fitted camera, inserted through a small cut in the lower abdomen, is used to visualize and remove the cyst.

Corpus Luteum Cyst Rupture During Pregnancy

Cysts can sometimes rupture and cause acute pain in the lower abdomen. The doctor may prescribe certain pain relief medications, following which the cyst usually heals.

A ruptured cyst can sometimes lead to hemoperitoneum, a condition characterized by a blood-filled peritoneal cavityiThe space between the inner lining of the abdomen and the outer layer of the abdominal organs . The condition generally requires a laparoscopic or laparotomyiA surgical incision into the abdomen to diagnose any problems surgery based on its severity (10) (11).

Corpus Luteum Cyst Torsion During Pregnancy

A growing corpus luteum cyst may add weight to the ovary, causing it to twist on itself or the surrounding tissues. When an ovarian torsion occurs, the blood supply to the ovary is obstructed causing severe pain and sometimes vomiting and may require immediate surgery (12).

Frequently Asked Questions

1. Can a corpus luteum cyst cause miscarriage?

Typically, a corpus luteum cyst does not interfere with the pregnancy but helps sustain it by producing the progesterone hormone and disappears by the second trimester. However, a corpus luteum cyst can become hemorrhagic, where blood fills the cyst cavity, causing acute abdominal pain. Seeking medical attention helps prevent the risk of miscarriage (13).

2. Can a corpus luteum cyst be cancerous?

A corpus luteum cyst, being a functional cyst, is usually not cancerous. However, some conditions associated with corpus luteum cysts, such as endometriosis and PCOS, are associated with an increased risk of developing ovarian cancer. Further, ovarian cancer can sometimes show as a luteal cyst. Your doctor may conduct different tests based on the cyst’s size and symptoms to identify any chance of malignancy (14) (15).

3. Can a corpus luteum cyst cause a positive pregnancy test?

Pregnancy can cause corpus luteum cysts. However, a corpus luteum cyst can sometimes give a false positive pregnancy result due to increased hCG levels. Your healthcare practitioner may perform additional tests, such as pelvic examination, ultrasound, and blood tests, to confirm the results (16)  (17).

4. What does the corpus luteum look like on an ultrasound?

A corpus luteum is a thick-walled cyst having a typical ‘ring of fire’ peripheral vascularity on color Doppler ultrasound. It is usually seen with a crenulated (ridge-like) inner margin (18).

5. Can a corpus luteum cyst be mistaken for a gestational sac?

The corpus luteum may be confused with the ectopic pregnancy’s gestational sac. However, a reliable way of distinguishing it from ectopic pregnancy is by identifying the location of the lesion. Corpus luteum arises from the ovary, while most ectopic pregnancies are tubal (19).

6. What are the long-term effects of corpus luteum cysts on fertility?

Luteum cysts typically do not have long-term effects on fertility, as they are often self-resolving. However, persistent cysts or those linked to conditions like PCOS may need frequent monitoring.

Corpus luteum cysts in pregnancy are common and generally dissolve over time. However, if you experience symptoms such as severe abdominal pain, high fever, or bleeding, consult your doctor to avoid any complications. When detected early, the symptoms can be treated easily with the help of oral contraceptives. In case of mild symptoms, your doctor may recommend pregnancy monitoring to ensure the symptoms do not aggravate. With timely intervention and proper maternal care, complications such as corpus luteum cyst rupture and corpus luteum cyst torsion can be prevented.

Infographic: What Conditions Can Mimic Corpus Luteum Cysts In Pregnancy?

Corpus luteum cyst in pregnancy is mostly harmless and often resolves without any interventions. If the imaging is not clear, your doctor may order a few other tests to exclude some gynecological or acute abdomen conditions requiring immediate attention. Go through the infographic to know the conditions that may be mistaken for corpus luteum cyst and how it is differentiated.

corpus leuteum (infographic)

Illustration: Momjunction Design Team

Key Pointers

  • Corpus luteal cysts are harmless when they turn into a luteal cyst as they can produce progesterone.
  • Transvaginal and transabdominal ultrasounds can help detect corpus luteum cyst size, shape, and location.
  • Ovarian cyst symptoms include pelvic pain during period, pain during intercourse, unusual swelling or bloating of the abdomen, etc.

Illustration: Corpus Luteum Cyst In Pregnancy: Symptoms And Treatment

Corpus Luteum Cyst In Pregnancy_illustration

Image: Dall·E/MomJunction Design Team


Learn about the Corpus Luteum Cyst – a fluid-filled sac that can form in a woman’s ovary. Hear the medical definition and pronunciation of this condition.

References

MomJunction's articles are written after analyzing the research works of expert authors and institutions. Our references consist of resources established by authorities in their respective fields. You can learn more about the authenticity of the information we present in our editorial policy.
  1. Corpus luteal cyst.
    https://radiopaedia.org/articles/corpus-luteal-cyst
  2. Baerwald A.R. et al.; (2005); Form and function of corpus luteum during human menstrual cycle.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882116/
  3. Ovarian cysts.
    https://www.womenshealth.gov/a-z-topics/ovarian-cysts
  4. What Risks Are Associated With Ruptured Ovarian Cysts?
    https://www.hopkinsmedicine.org/health/conditions-and-diseases/what-risks-are-associated-with-a-ruptured-ovarian-cyst
  5. Ovulation and the phases of the menstrual cycle.
    https://www.avogel.co.uk/health/periods/ovulation-and-the-menstrual-cycle/
  6. The Menstrual Cycle.
    https://www.ucsfhealth.org/education/the-menstrual-cycle
  7. Ovarian cysts.
    https://medlineplus.gov/ency/article/001504.htm
  8. Ovarian Cysts.
    https://www.acog.org/womens-health/faqs/ovarian-cysts
  9. Ovarian Cyst.
    https://www.cedars-sinai.org/health-library/diseases-and-conditions/o/ovarian-cyst.html
  10. Corpus luteal cyst rupture.
    https://radiopaedia.org/articles/corpus-luteal-cyst-rupture
  11. Kishore Pandit et al.; (2018); Massive Hemoperitoneum from a Ruptured Corpus Luteal Cyst.
    https://pdfs.semanticscholar.org/acaa/944d531d408b65026d63fc0b6451290df0f2.pdf
  12. Ovarian Torsion.
    https://www.yalemedicine.org/conditions/ovarian-torsion
  13. Mykhailo V Medvediev et. al.; (2020); Hemorrhagic corpus luteum cyst: Clinical management update.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731611/
  14. Ovarian Cysts: What Are the Risks?
    https://www.roswellpark.org/cancertalk/201709/ovarian-cysts-what-are-risks
  15. Science Made Simple: Ovarian Cysts and Ovarian Cancer.
    https://ocrahope.org/news//science-made-simple-ovarian-cysts-and-ovarian-cancer/
  16. 7 Reasons Your Pregnancy Test Gave AFalse Positive.
    https://www.thesource.org/post/reasons-your-pregnancy-test-gave-a-false-positive
  17. Ovarian Cysts.
    https://utswmed.org/conditions-treatments/ovarian-cysts/
  18. Corpus luteum.
    https://radiopaedia.org/articles/corpus-luteum#:~:text=Ultrasound
  19. Robert Lee et al.; (2018); Diagnosing ectopic pregnancy in the emergency setting.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769947/
  20. Ubong Bassey Akpan et al.; (2021); A twisted giant corpus luteum cyst in the third trimester of pregnancy in a multigravida: A case report.
    https://www.researchgate.net/publication/355409817_A_twisted_giant_corpus_luteum_cyst_in_the_third_trimester_of_pregnancy_in_a_multigravida_A_case_report
  21. Corpus Luteum Cyst
    https://my.clevelandclinic.org/health/diseases/22340-corpus-luteum-cyst#:~:text=A%20corpus%20luteum%20cyst%20is
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Dr. Richa Hatila Singh
Dr. Richa Hatila SinghMS
Dr. Richa Hatila is a practicing gynecologist in Varanasi, with 14 years of experience. She did her MS in Obstetrics and Gynaecology, DNB, and a Fellowship in Laparoscopic surgeries (FMAS). She is currently associated with Shubham Hospital and Sah Speciality Clinic in Varanasi.

Read full bio of Dr. Richa Hatila Singh
Aneesha Amonz
Aneesha AmonzMSc
Aneesha holds a Bachelor's degree in Biotechnology from USTM, Meghalaya and Master’s degree in Applied Microbiology from VIT, Vellore. With two years of experience, she has worked on different research projects in the field of Food Sciences.

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Rebecca Malachi
Rebecca MalachiBSc
Rebecca is a pregnancy writer and editor with a passion for delivering research-based and engaging content in areas of fertility, pregnancy, birth, and post-pregnancy. She did her graduation in Biotechnology and Genetics from Loyola Academy, Osmania University and obtained a certification in ‘Nutrition and Lifestyle in Pregnancy’ from Ludwig Maximilian University of Munich (LMU).

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Reshmi Das
Reshmi DasMSc
Reshmi Das has over four years of experience as a clinical coordinator, medical content writer and medical conference coordinator. Her continuous interest in medical journals and writing makes her write well-researched articles for MomJunction.

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