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Malaria in babies is more prevalent in tropicaliRelated to a region that has hot and humid weather. and subtropicaliArea on the earth in the north and south region of the tropics or equator. regions. It is a parasitic disease transmitted to humans through the bite of an infected mosquito. Babies born to mothers with malaria during pregnancy have an increased risk of developing malaria in the first few days of life, called congenital malaria.
High fever and shaking chills are some initial symptoms of malaria in babies. Although anyone can contract malaria, babies between six months to five years are most vulnerable to severe symptoms and complications.
Read on to know about the causes, symptoms, treatment, and prevention of malaria in babies.
Key Pointers
- Malaria is a transmittable disease, mostly affecting babies between six months and five years.
- An infected mosquito bite or congenital malaria are common causes of this disease in babies.
- Fatigue, fever, muscle pains, and changes in breathing rate are common signs of malaria.
- Combinational, artemisinin-based therapy is a treatment advised by WHO for babies with malaria.
How Common Is Malaria In Babies?
According to the World Health Organization, children younger than five years accounted for 67% of fatalities due to malaria in 2019(1)(2)
. Inadequate immunity is usually the common reason why babies and toddlers could be more susceptible to a severe form of the disease.
California-based board-certified obstetrician-gynecologist Dr. Michael Green says, “Malaria can impact individuals of all ages, but young children and pregnant women are particularly vulnerable to severe complications and death from the infection. Children under five years old are at the highest risk of severe malaria and mortality, as their immune systems are still developing and they may not have acquired immunity to the disease.”
Babies usually also do not have adequate skills to avoid mosquitoes, which are the vector of malaria. Several babies in malaria-endemic regions with poor public health and vector control may also experience maternal malaria since malarial parasites can reach the fetus (3). It may lead to poor health and low immunity at birth, further increasing the risk of malaria.
What Causes Malaria In Babies?
Causes and transmission of Malaria can occur through the following ways (4) (5).
1. Bite of Anopheles mosquito
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Malaria is caused by a parasite called plasmodium, which is transmitted through the bite of an infected female Anopheles mosquito. The mosquito gets the parasite when it feeds on the blood of a person with malaria. The parasite stays in the Anopheles mosquito’s saliva, making the insect a vector for the disease.
When the mosquito bites an uninfected person, the parasite transmits from the insect’s saliva into the person’s bloodstream. Once inside the body, the parasites reach the liver, where they mature and multiply. The mature parasites move back into the bloodstream, infecting the red blood cells.
The mature malarial parasites multiply in infected red blood cells, causing the cell to rupture and infect other red blood cells. This breakdown of red blood cells happens every 48-72 hours, triggering the symptoms.
There are five types of plasmodium that cause malaria in humans.
- Plasmodium falciparum: It is the most common type of plasmodium and responsible for most malaria-related deaths. The parasite is predominantly found in Africa.
- Plasmodium vivax: It is mostly found in Asia and South America. The parasite causes less severe symptoms but could stay dormantiPhase when an organism is not physiologically active but is capable of becoming active. in the liver for three years, causing relapses in a few cases.
- Plasmodium ovale: It is primarily found in West Africa and is uncommon.
- Plasmodium malariae: It is a less common type of parasite and is only found in parts of Africa.
- Plasmodium knowlesi: It is a rare form of the parasite and only found in Southeast Asia.
2. Congenital malaria
Since malarial parasites infect red blood cells, they can reach the fetus through the placentaiAn organ that develops in the uterus and provides oxygen and nutrients to the baby. . A baby could be born with malaria at birth (congenital malaria) if the maternal health was compromised due to the mother developing malaria anytime during the pregnancy. It may cause low birth weight and a high risk of mortality, especially during the first month.
According to a study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology, congenital malaria’s overall prevalence was 6.9% (562/8148). The condition tends to be common in settings with poor prenatal care and in regions where malaria cases are widespread due to environmental factors and social determinants, such as poverty, poor sanitation, and hygiene.
3. Infected donor blood
A baby may receive plasmodium from the blood of a donor infected with malaria. It may also transmit through the use of infected needles. Such cases are rare and usually occur in healthcare settings that lack even basic safety protocols.
Can A Baby Get Malaria Through Breast Milk?
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A baby cannot get malaria by breastfeeding since maternal transmission is not possible since the plasmodium parasite does not transmit through breast milk (6). However, malaria medication may pass into breast milk. If you have malaria and intend to breastfeed, speak to your doctor before initiating treatment.
Quick factSymptoms Of Malaria In Babies
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Babies with malaria could show the following symptoms (7) (8).
- Fever: Babies could develop high fever accompanied by strong chills and sweating. The fever may cause febrile convulsionsiThe fits observed in children while having high fever. in some babies.
- Cough: Cough is often an early symptom of malaria.
- Gastric symptoms: It includes nausea, stomach pain, vomiting, and acute diarrhea.
- Pain: Muscle pain and headaches are usually most common. Toddlers may also complain of pain in specific body parts, such as the back.
- Fatigue: Babies with malaria could feel tired, weak, and drowsy. They might also become cranky, develop a poor appetite, and have problems falling asleep.
- Jaundice: Malaria leads to a constant breakdown of red blood cells, causing excess accumulation of bilirubin, which is a byproduct of the red blood cell breakdown. This could cause bilirubin accumulation in the body, leading to jaundice in some babies.
- SeizuresiUncontrollable surge of electrical activity in the brain.
- Rapid breathing
- Small babies may have low body temperature (hypothermiaiHealth condition showing critically low body temperature. ) instead of a fever
Malaria caused by plasmodium falciparum may become severe if left untreated for 24 hours. It may lead to severe symptoms and related complications, such as cerebral malaria, respiratory problems, metabolic acidosis (increased acidity in blood and tissue fluids), and severe anemiaiCondition when there is a deficiency of red blood cells in the blood. (1).
Many of these symptoms may occur due to other illnesses. Therefore, consult a pediatrician soon if the baby displays these signs and symptoms.
Quick factHow Is Malaria Diagnosed?
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The doctor will check the symptoms. Parents may be asked about any travel history to malaria-endemiciAn area that is more susceptible to certain diseases or conditions. regions. If malaria is suspected, the doctor may order the following tests to make a diagnosis (9).
- Blood tests: Plasmodium parasites are visible under the microscope. A smear of the patient’s blood is taken, stained, and observed under the microscope.
- Rapid diagnostic tests (RDT): Rapid diagnostic tests can be used if microscopic tests are unavailable. These tests detect the malarial antigens using the dipstick or cassette format. It takes only 2-15 minutes to get the result.
How Is Malaria In Babies Treated?
The World Health Organization suggests the use of artemisinin to treat uncomplicated malaria in infants(10)
. The drug is used in combination with other medicines, and the treatment is called artemisinin-based combination therapy. A combination treatment could help prevent plasmodium resistance.
The dosage of artemisinin and other medicines will depend on several factors, such as the baby’s weight and the severity of symptoms. The mode of administration could be intravenous or oral.
In addition to antimalarial medications, supportive care is essential for infants suffering from malaria. This may include hydration, nutritional support, and management of fever and pain. Close monitoring in a healthcare setting is advised, especially for severe cases.
Severe cases of malaria could require treatment with rectal artesunate. Complicated cases of malaria could require treatment with intravenous artesunate (11). The duration of treatment could vary as per the baby’s health and the severity of symptoms.
What Are The Long-Term Effects Of Malaria On Babies?
Most cases of uncomplicated malaria seldom cause any long-term problems. Research notes that malaria in young children may affect the child’s physical and cognitive development temporarily (12). These effects may mostly occur due to untreated severe and complicated malaria.
Research findsHow To Prevent Malaria In Babies?
The following measures could help prevent malaria in infants.
1. Avoiding mosquito bites
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An effective way to prevent malaria is to prevent mosquito bites in babies. Below are ways to protect your baby from mosquito bites (13) (14).
- Attach a mosquito net to the windows to keep mosquitoes out.
- You may attach mosquito bed nets to your baby’s crib and your bed as well. Make sure to check for any trapped mosquitoes inside the net before placing the baby in the crib.
- You may use air conditioning or fans to keep mosquitoes out.
- Dress your baby in light-colored clothing that covers the limbs when visiting places that may have mosquitoes, such as parks.
- You may apply insect-repellent cream to the exposed skin. However, many insect repellents are not recommended for babies and toddlers. Consult a doctor before using insect repellent for your baby.
2. Preventing malaria through medicines
Preventive medications could be considered when avoiding mosquitoes is difficult. A common therapy used is the intermittent preventive therapy in infants (IPTi) with sulfadoxine-pyrimethamine (SP). The therapy is called SP-IPTi (15).
The therapy is similar to a vaccination and involves the administration of sulfadoxine-pyrimethamine at the ages of ten weeks, 14 weeks, and nine months. Other medicines, such as amodiaquine, may also be used. The preventive therapy causes sustained quantities of malarial drugs in the blood, preventing symptoms even if the baby contracts the parasite (16).
Preventive therapy may have contraindications and may only be necessary if you live in a malaria-endemic region with no facilities to control mosquito populations.
Point to considerFrequently Asked Questions
1. Can antibiotics treat malaria in babies?
A protozoan parasite causes malaria, which is treated with antiparasitic drugs. Some antibiotics may have antimalarial effects, too (17). But, since antimalarial drugs are readily available and antibiotics can have side effects, it is uncommon to use antibiotics to treat malaria.
2. What happens if a mosquito bites my newborn?
Mosquito bites are often common in newborns and may cause itchiness and red bumps; however, mosquito bites of some species may cause serious diseases, including yellow fever or malaria (18).
3. What is the difference between fever and malarial fever in babies?
If your baby has fever along with strong chills, rapid breathing, sweating, body pain, lethargy, and various gastrointestinal problems, it could indicate malarial fever, especially if you’re living in an endemic malaria zone (8).
Malaria in babies may be transmitted by biting an infected female anopheles mosquito or from the mother if infected during pregnancy. The plasmodium infection may manifest in babies as fever, cough, fatigue, gastrointestinal disturbances, or jaundice. In combination with other medications, Artemisinin is usually recommended to treat infants affected with malaria. Preventing mosquito bites is an effective way of protecting your baby and may be achieved by installing mosquito nets on windows and cribs. Consult a doctor before using any mosquito-repellent creams.
Infographic: Traveling To Malaria-Endemic Regions With Babies
While it is recommended that infants should not travel to malaria-endemic regions, this infographic will be of great help if you must. Find all the necessary tips to prepare for the trip and the precautions you must take to keep your baby safe and healthy. Illustration: Momjunction Design Team
Get practical and efficient techniques to address malaria in infants. Find up-to-date recommendations and guidance on ensuring the safety of your baby.
References
1. Malaria; World Health Organization
2. Malaria: Overview NHS UK
3. Richard-Fabian Schumacher and Elena Spinelli, Malaria in Children; U.S. National Library of Medicine
4. Malaria; U.S. National Library of Medicine
5. Malaria: Causes; NHS UK
6. Malaria; CDC
7. Lauren M. Cohee and Miriam K. Laufer, Malaria in Children; U.S. National Library of Medicine
8. Malaria; National Organization for Rare Disorders
9. Malaria Diagnostic Tests; CDC
10. Malaria in infants; World Health Organization
11. Malaria in children under five; World Health Organization
12. Nutchavadee Vorasan et al., Long-term impact of childhood malaria infection; U.S. National Library of Medicine
13. Malaria: Prevention; NHS UK
14. Choosing an Insect Repellent for Your Child; American Academy of Pediatrics
15. Jamie T. Griffin et al.; Protective Efficacy of Intermittent Preventive Treatmentof Malaria in Infants (IPTi) Using Sulfadoxine-Pyrimethamine and Parasite Resistance; ResearchGate
16. Seasonal malaria chemoprevention (SMC); World Health Organization
17. Erica L. Dahl and Philip J. Rosenthal, Multiple Antibiotics Exert Delayed Effects against the Plasmodium falciparum Apicoplast; ASM Journals
18. Mosquito Bite; Seattle Children’s Hospital
19. Malaria; NHS Inform
20. Erin M. Milner et al.; Association between Malaria Infection and Early
Childhood Development Mediated by Anemia in Rural Kenya; NCBI
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Read full bio of Dr. Ashraf Kasem
Dr. Michael Green is a board-certified OB/GYN living in Lake Arrowhead, CA. He studied medicine at St. Louis University of Medicine and completed a Family Medicine Residency at the Ventura County Medical Center. Dr. Green did a second residency in Obstetrics and Gynecology at The Carolinas Medical Center in Charlotte, NC. In addition, he holds a masters degree in Chemistry from the California State University Northridge. With over 17 years experience, Dr. Green currently works as a site director for OBHG at Northridge Medical Center in Northridge, CA.Dr. Michael Green is a board-certified OB/GYN living in Lake Arrowhead, CA. He studied medicine at St. Louis University of Medicine and completed a Family Medicine Residency at the Ventura County Medical Center. Dr. Green did a second residency in Obstetrics and Gynecology at The Carolinas Medical Center in Charlotte, NC. In addition, he holds a masters degree in Chemistry from the California State University Northridge. With over 17 years experience, Dr. Green currently works as a site director for OBHG at Northridge Medical Center in Northridge, CA.
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